157260

1-Hydroxybenzotriazole hydrate

98% dry basis wetted with not less than 14 wt. % water, for peptide synthesis

• Synonym(s): HOBt Hydrate
• Empirical Formula (Hill Notation): C₆H₅N₃O · xH₂O
• CAS Number: 123333-53-9
• Molecular Weight: 135.12 (anhydrous basis)
• MDL number: MFCD00065690
• UNSPSC Code: 12352000
• PubChem Substance ID: 24849666
• NACRES: NA.22
• EC Number: 219-989-7
• Beilstein/REAXYS Number: 4515

Properties

• Product Name: 1-Hydroxybenzotriazole hydrate, wetted with not less than 14 wt. % water, 98% dry basis
• SMILES string: [H]O[H].On1nnc2ccccc12
• InChI: 1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
• InChI key: PJUPKRYGDFTMTM-UHFFFAOYSA-N
• assay: 98% dry basis
• form: solid
• quality: synthesis grade
• reaction suitability: reaction type: Addition Reactions
• mp: 155-158 °C (lit.)
• application(s): peptide synthesis
• Quality Level: 200

Description

Application

1-Hydroxybenzotriazole hydrate can be used as a reagent:

• To synthesize β-peptides via microwave-assisted amino acid coupling.
• In the spot synthesis of glycopeptides.

It can also be used as a deprotection agent for the removal of Fmoc (9-fluorenylmethoxycarbonyl) protecting group.

General description

1-Hydroxybenzotriazole hydrate is a derivative of benzotriazole primarily used as a coupling reagent in peptide synthesis.

Safety Information

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H207,H319,H412
• pcodes: P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501
• Hazard Classifications: Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2
• supp_hazards: EUH044
• Storage Class: 4.1A - Other explosive hazardous materials
• wgk: WGK 1
• flash_point_f: 314.6 °F
• flash_point_c: 157 °C