Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Organic letters (2005-05-07)

Benedek Vakulya, Szilárd Varga, Antal Csámpai, Tibor Soós

ABSTRACT

Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.

MATERIALS

Product Number

Brand

Product Description

360554

Sigma-Aldrich

Nitromethane, ACS reagent, ≥95%

Pricing and availability is not currently available.

270423

Sigma-Aldrich

Nitromethane, suitable for HPLC, ≥96%

Pricing and availability is not currently available.

230731

Sigma-Aldrich

Nitromethane, ReagentPlus^®, ≥99.0%

Pricing and availability is not currently available.