Phosphatases at the heart of FoxO metabolic control.

Cell metabolism (2008-02-06)
Michel L Tremblay, Vincent Giguère
ABSTRACT

FoxO transcription factors contribute to cardiac muscle remodeling and insulin signaling, but how they link insulin resistance and maladaptive heart hypertrophy remains unknown. A new study by Ni et al. (2007) shows that sustained activation of FoxO1 or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling through inhibition of calcineurin and PP2A.

MATERIALS
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Product Description

Sigma-Aldrich
MISSION® shRNA Mouse Gene Family Set, DNA, Phosphatases
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