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Protein tyrosine phosphatases: functional inferences from mouse models and human diseases.

The FEBS journal (2008-02-27)
Wiljan J A J Hendriks, Ari Elson, Sheila Harroch, Andrew W Stoker
ABSTRACT

Some 40-odd genes in mammals encode phosphotyrosine-specific, 'classical' protein tyrosine phosphatases. The generation of animal model systems and the study of various human disease states have begun to elucidate the important and diverse roles of protein tyrosine phosphatases in cellular signalling pathways, development and disease. Here, we provide an overview of those findings from mice and men, and indicate several novel approaches that are now being exploited to further our knowledge of this fascinating enzyme family.

MATERIALS
Product Number
Brand
Product Description

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