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ABCC2

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Synonimy:
ABC30, CMOAT, DJS, MRP2, cMRP
Gatunek:
Human ABCC2 (1244), Mouse Abcc2 (12780), Rat Abcc2 (25303), sheep ABCC2 (101119776), Horse ABCC2 (100060654), naked mole-rat Abcc2 (101716089), domestic guinea pig Abcc2 (100718828), cow ABCC2 (520925), domestic cat ABCC2 (101085924), dog ABCC2 (403632) ...Więcej
Identyfikator UniProtKB:
Q92887, B2RMT8, Q14022, Q5T2B1, Q92500, Q92798, Q99663, Q9UMS2
Identyfikator genu:
  • Human(1244) Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
  • Mouse(12780) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Rat(25303) ATP-binding cassette, subfamily C (CFTR/MRP), member 2
  • sheep(101119776) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Horse(100060654) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • naked mole-rat(101716089) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • domestic guinea pig(100718828) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • cow(520925) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • domestic cat(101085924) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • dog(403632) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • chicken(423828) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Zebrafish(393561) ATP-binding cassette, sub-family C (CFTR/MRP), member 2

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Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
SAB1403681
Monoclonal Anti-ABCC2 antibody produced in mouse, clone 2H6, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
immunofluorescence
western blot
MABN1545
Anti-MRP2 Antibody, clone 4C9.2, clone 4C9.2, from mouse,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
MAB4148
Anti-MRP2 Antibody, clone M2 I-4, culture supernatant, clone M2 I-4, Chemicon®,
Reaktywność gatunkowa
human
Zastosowanie
immunocytochemistry
immunohistochemistry
western blot
M3692
Anti-MRP2 antibody, Mouse monoclonal, clone CPR96, purified from hybridoma cell culture,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
microarray
western blot
SAB5702744
Przeciwciało anty-MRP2/ABCC2, klon 6L3Z6, królicze monoklonalne, ,
Reaktywność gatunkowa
human
Zastosowanie
western blot

Cell Lines

Numer produktu
Opis
Gatunek
MTOX1020
HepaRG™ Komórki MRP2 (-/-), one vial,
Gatunek
human
MTOX1005
Komórki Caco-2 z podwójnym nokautem MDR1/MRP2, one vial,
Gatunek
human
MTOX1006
Komórki Caco-2 z podwójnym nokautem BCRP/MRP2, one vial,
Gatunek
human

Kits

Numer produktu
Opis
Gatunek
MAK161
Multidrug Resistance Assay Kit, (Fluorometric MDR Assay),
Gatunek
human, mouse, rat

esiRNA

Numer produktu
Opis
Gatunek
EHU052041
MISSION® esiRNA, targeting human ABCC2,
Gatunek
human