CHEK1
checkpoint kinase 1
Synonimy:
CHK1
Gatunek:
Human CHEK1 (1111), Mouse Chek1 (12649), Rat Chek1 (140583), naked mole-rat Chek1 (101701035), sheep CHEK1 (101111403), domestic guinea pig Chek1 (100719613), Zebrafish chek1 (393162), domestic cat CHEK1 (101083365), dog CHEK1 (609767), Horse CHEK1 (100064353)
Identyfikator UniProtKB:
Identyfikator genu:
- Human(1111) Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
- Mouse(12649) checkpoint kinase 1
- Rat(140583) checkpoint kinase 1
- naked mole-rat(101701035) checkpoint kinase 1
- sheep(101111403) checkpoint kinase 1
- domestic guinea pig(100719613) checkpoint kinase 1
- Zebrafish(393162) CHK1 checkpoint homolog (S. pombe)
- domestic cat(101083365) checkpoint kinase 1
- dog(609767) checkpoint kinase 1
- Horse(100064353) checkpoint kinase 1
- cow(513678) CHK1 checkpoint homolog (S. pombe)
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Monoclonal Anti-CHEK1 antibody produced in mouse, clone 2G3, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
immunofluorescence
immunofluorescence
Anti-Chk1 antibody, Mouse monoclonal, ~2 mg/mL, clone DCS-310, purified from hybridoma cell culture,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
immunoprecipitation (IP)
microarray
western blot
Anti-phospho-Chk1 (pSer345) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry
immunohistochemistry
Przeciwciało anty-Chk1, klon 0S3Q1, królicze monoklonalne, ,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
western blot
Przeciwciało anty-fosfoCHEK1-S296wytwarzane u królika, ,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunofluorescence
western blot
western blot
Small Molecule - Inhibitor
Numer produktu
Opis
Gatunek
Proteins
Numer produktu
Opis
Gatunek
CHK1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Gatunek
human
CHK1, active, His tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Gatunek
human
Białko CHK1, aktywne, 10 µg, Active, N-terminal GST tagged, human full length CHK1, for use in Kinase Assays.,
Gatunek
human
esiRNA
Numer produktu
Opis
Gatunek
Small Molecule - Substrate
Numer produktu
Opis
Gatunek
CHKtide (peptyd substratowy CHK1/CHK2), CHKtide (CHK1/CHK2 substrate peptide) primarily used in Kinase Assays.,
Gatunek
human