DCTN1
dynactin 1
Synonimy:
DAP-150, DP-150, P135
Gatunek:
Human DCTN1 (1639), Mouse Dctn1 (13191), Rat Dctn1 (29167), naked mole-rat Dctn1 (101703706), domestic guinea pig Dctn1 (100714202), Domestic Rabbit DCTN1 (100346609), sheep DCTN1 (101116037), cow DCTN1 (511045), domestic cat DCTN1 (101084533), Horse DCTN1 (100053938) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(1639) Summary: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
- Mouse(13191) dynactin 1
- Rat(29167) dynactin 1
- naked mole-rat(101703706) dynactin 1
- domestic guinea pig(100714202) dynactin 1
- Domestic Rabbit(100346609) dynactin 1
- sheep(101116037) dynactin 1
- cow(511045) dynactin 1
- domestic cat(101084533) dynactin 1
- Horse(100053938) dynactin 1
- dog(483106) dynactin 1
- chicken(426238) dynactin 1
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Przeciwciało anty-Dctn1 wytwarzane u królików, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
Anty-DCTN1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Anti-DCTN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-DCTN1 Antibody, clone 2B11 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reaktywność gatunkowa
human, mouse, nonhuman primates
Zastosowanie
affinity binding assay
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Monoclonal Anti-DCTN1 antibody produced in mouse, clone 1E12, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
western blot
western blot
esiRNA
Numer produktu
Opis
Gatunek