MAP2K4
mitogen-activated protein kinase kinase 4
Synonimy:
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
Gatunek:
Human MAP2K4 (6416), Mouse Map2k4 (26398), Rat Map2k4 (287398), domestic cat MAP2K4 (101086432), Domestic Rabbit MAP2K4 (100344852), chicken MAP2K4 (417312), dog MAP2K4 (489508), sheep MAP2K4 (101115045), Horse MAP2K4 (100073094), domestic guinea pig Map2k4 (100733674) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(6416) Summary: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul 2008]
- Mouse(26398) mitogen-activated protein kinase kinase 4
- Rat(287398) mitogen activated protein kinase kinase 4
- domestic cat(101086432) mitogen-activated protein kinase kinase 4
- Domestic Rabbit(100344852) mitogen-activated protein kinase kinase 4
- chicken(417312) mitogen-activated protein kinase kinase 4
- dog(489508) mitogen-activated protein kinase kinase 4
- sheep(101115045) mitogen-activated protein kinase kinase 4
- Horse(100073094) mitogen-activated protein kinase kinase 4
- domestic guinea pig(100733674) mitogen-activated protein kinase kinase 4
- naked mole-rat(101705822) mitogen-activated protein kinase kinase 4
- cow(526469) mitogen-activated protein kinase kinase 4
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-phospho-SEK1/MKK4/JNKK1 (pSer257) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry
immunohistochemistry
Anti-MAP2K4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
western blot
western blot
Anti-MAP2K4 (Ab-80) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunohistochemistry
western blot
western blot
Anti-Phospho-MAP2K4-S257, ,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
western blot
Anti-Phospho-MAP2K4-T261, ,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Numer produktu
Opis
Gatunek
Proteins
Numer produktu
Opis
Gatunek
Białko MKK4/SKK1, aktywne, 10 µg, Active, N-terminal GST tagged, murine MKK4 residues 34-end, for use in Kinase Assays.,
Gatunek
mouse
Białko MKK4/SKK1, nieaktywne, 50 g, Unactive, recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an N-terminal GST-tag, for use in Kinase Assays.,
Gatunek
mouse