Merck
All Photos(1)

P215

Sigma-Aldrich

PD 98,059

solid

Synonym(s):
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059
Empirical Formula (Hill Notation):
C16H13NO3
CAS Number:
Molecular Weight:
267.28
Numer MDL:
Identyfikator substancji w PubChem:

Poziom jakości

100

forma

solid

kolor

yellow

rozpuszczalność

DMSO: 10 mg/mL, clear

temp. przechowywania

−20°C

SMILES string

COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

InChI

1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChI key

QFWCYNPOPKQOKV-UHFFFAOYSA-N

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Zastosowanie

PD 98,059 has been used:
  • in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
  • in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
  • in culture medium for cell migration assay

Opakowanie

1, 5 mg in glass bottle

Działania biochem./fizjol.

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Cechy i korzyści

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informacje prawne

Sold with permission of Warner Lambert Company.

Kod klasy składowania

11 - Combustible Solids

WGK

WGK 3

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificate of Analysis

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Certificate of Origin

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