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Merck

PDE4A

phosphodiesterase 4A, cAMP-specific

Synonimy:
DPDE2, PDE4, PDE46
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(5141) Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
  • Mouse(18577) phosphodiesterase 4A, cAMP specific
  • Rat(25638) phosphodiesterase 4A, cAMP-specific
  • sheep(101117505) phosphodiesterase 4A, cAMP-specific
  • Domestic Rabbit(100009247) phosphodiesterase 4A, cAMP-specific
  • Zebrafish(572061) phosphodiesterase 4A, cAMP-specific
  • domestic cat(751107) phosphodiesterase 4A, cAMP-specific
  • dog(100683695) phosphodiesterase 4A, cAMP-specific
  • chicken(769860) phosphodiesterase 4A, cAMP-specific
  • domestic guinea pig(100135594) phosphodiesterase 4A, cAMP-specific
  • cow(512222) phosphodiesterase 4A, cAMP-specific
  • naked mole-rat(101717168) phosphodiesterase 4A, cAMP-specific

Custom & Knockdown Gene Products

Small Molecule - Activator

Numer produktu
Opis
Gatunek
Rolipram, solid, ≥98% (HPLC),
Gatunek
human, mouse, rat

Small Molecule - Antagonist

Numer produktu
Opis
Gatunek
4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one, solid,
Gatunek
human, rat
Theophylline, United States Pharmacopeia (USP) Reference Standard,
Gatunek
human
Theophylline, Pharmaceutical Secondary Standard; Certified Reference Material,
Gatunek
human
Wzorzec temperatury topnienia teofiliny, United States Pharmacopeia (USP) Reference Standard,
Gatunek
human
Theophylline, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anty-PDE4A, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Anti-PDE4A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
Zaprinast, solid,
Gatunek
human
Ibudilast, ≥99% (HPLC), solid,
Gatunek
human
Roflumilast, ≥98% (HPLC),
Gatunek
human
Amlexanox, ≥98% (HPLC),
Gatunek
human
7-(2,3-Dihydroxypropyl)theophylline, ,
Gatunek
human

Proteins

Numer produktu
Opis
Gatunek
PDE4A1A Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Gatunek
human
PDE4A4B active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥40% (SDS-PAGE),
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human PDE4A (3),
Gatunek
human
MISSION® esiRNA, targeting human PDE4A,
Gatunek
human
MISSION® esiRNA, targeting human PDE4A (2),
Gatunek
human
MISSION® esiRNA, targeting mouse Pde4a,
Gatunek
mouse