324801
Epoxomicin
≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem®
Synonim(y):
InSolution Epoxomicin, Synthetic, Proteasome Inhibitor XIV
Wybierz wielkość
| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
50 μg | Przewidywany termin wysyłki13 października 2026zKuehne + Nagel Sp. z o.o. | 863,00 zł |
Informacje o tej pozycji
863,00 zł
Przewidywany termin wysyłki13 października 2026Szczegóły
Nazwa produktu
Epoxomicin, InSolution, ≥95%
Quality Segment
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
−20°C
General description
Product does not compete with ATP.
Reversible: No
Epoxomicin is a highly effective and selective proteasome inhibitor thatexhibits significant anti-inflammatory properties in vivo. This potent antitumor agent specifically targets the proteasome. Epoxomicin exhibits a stronger inhibitory effect on chymotrypsin-like activity compared to lactacystin and the peptide vinyl sulfone (NLVS). This powerful natural producteffectively inhibits nuclear factor kappa B (NF-κB) activation in vitro and signific antly reduces inflammation in the murine ear edema assay. Epoxomicin prevents the degradation of IκB and inhibits the activation of NF-κBDNA-binding activity. It can stabilize p53 levels in cell culture. It is an irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidylglutamyl peptide hydrolyzing (PGPH) activities of the proteasome. It modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z[MJ2] .
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Ta pozycja | |||
|---|---|---|---|
| description InSolution, ≥95% | description Epoxomicin, Synthetic, CAS 134381-21-8, is a potent, specific, and irreversible inhibitor of chymotrypsin-like, trypsin-like, and peptidyl-glutamyl peptide hydrolyzing activities of the proteasome. | description ≥95% (HPLC), solid | description InSolution, ≥95%, reversible proteasome inhibitor |
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) |
| form liquid | form solid | form solid | form liquid |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −70°C |
| storage condition OK to freeze, protect from light, desiccated (hygroscopic) | storage condition OK to freeze, protect from light | storage condition - | storage condition protect from light, avoid repeated freeze/thaw cycles, OK to freeze |
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Klasa składowania
10 - Combustible liquids
Co się dzieje?
WGK 1
Temperatura zapłonu (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Temperatura zapłonu (°C)
87 °C - closed cup - (Dimethylsulfoxide)
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