454565

Methyl Arachidonyl Fluorophosphonate - Calbiochem

• Synonim(y): Methyl Arachidonyl Fluorophosphonate - Calbiochem, MAFP, cPLA2α Inhibitor III
• Wzór empiryczny (zapis Hilla): C₂₁H₃₆FO₂P
• Masa cząsteczkowa: 370.48
• UNSPSC Code: 12352200

Właściwości

• assay: ≥98% (TLC)
• Quality Segment: 100
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• shipped in: wet ice
• storage temp.: −70°C

Opis

General description

This product has been discontinued.

A selective, active site-directed, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic (85 kDa) phospholipase A₂ (PLA₂) but not of secretory PLA₂.

A selective, active site-directed, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic (85 kDa) phospholipase A₂ (PLA₂) but not secretory PLA₂.

Biochem/physiol Actions

Cell permeable: no

Primary Target
calcium-dependent and calcium-independent cytosolic (85 kDa) phospholipase A2 (PLA2)

Product does not compete with ATP.

Reversible: no

Physical form

In methyl acetate.

Preparation Note

Prior to use, evaporate the methyl acetate and resuspend in high quality chloroform. Aliquot and immediately evaporate the chloroform. Store aliquots at -70°C. Reconstitute in DMSO just prior to use.

Other Notes

Balsinde, J., and Dennis, E.A. 1996. J. Biol. Chem. 271, 6758.
Lio, Y.C., et al. 1996. Biochim. Biophys. Acta1302, 55.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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