40809

Purine nucleoside phosphorylase

recombinant, expressed in E. coli, ≥120 U/mL

• Numer CAS: 9030-21-1
• UNSPSC Code: 12352204
• Numer WE: 2.4.2.1 (BRENDA, IUBMB)
• MDL number: MFCD00131739

Właściwości

• recombinant: expressed in E. coli
• form: buffered aqueous solution (100 mM phosphate buffer with 1 mM MgCl₂)
• specific activity: ≥120 U/mL
• storage temp.: −20°C
• InChI: 1S/C10H12N4O4/c15-2-6-7(16)8(17)10(18-6)14-4-13-5-1-11-3-12-9(5)14/h1,3-4,6-8,10,15-17H,2H2/t6-,7-,8-,10-/m1/s1
• InChI key: MRWXACSTFXYYMV-FDDDBJFASA-N

Opis

Application

Purine nucleoside phosphorylase is used to study nucleotide salvage pathways and purine metabolism. It is used to study purine nucleoside phosphorylase deficiency and responsible PNP genetic mutations.

Biochem/physiol Actions

Purine nucleoside phosphorylase is an enzyme involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine. Mutations in the PNP gene are responsible for purine nucleoside phosphorylase deficiency.

Other Notes

1 U will cause the phosphorolysis 1 μmol of inosine to hypoxanthine and ribose 1-phosphate per minute at pH 7.4 at 25°C

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable