A8129

AICAR

• Synonim(y): 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside, Acadesine, N¹-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
• Wzór empiryczny (zapis Hilla): C₉H₁₄N₄O₅
• Numer CAS: 2627-69-2
• Masa cząsteczkowa: 258.23
• EC Number: 220-097-5
• UNSPSC Code: 12352204
• MDL number: MFCD00869751

Właściwości

• SMILES string: NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N
• InChI: 1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
• InChI key: RTRQQBHATOEIAF-UUOKFMHZSA-N

Opis

Biochem/physiol Actions

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK).

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