PLA0233

Rabbit anti-BCR Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonim(y): ALL, BCR/FGFR1 chimera protein, BCR1, CML, D22S11, D22S662, FGFR1/BCR chimera protein, PHL, breakpoint cluster region, renal carcinoma antigen NY-REN-26
• NACRES: NA.41
• UNSPSC Code: 12352203
• Species reactivity: human
• Technique(s): flow cytometry: 0.25 μg, immunofluorescence: 1:500- 1:2,000, immunoprecipitation (IP): 10 μg/mg
• Application: FACS, IF, IP
• Citations: -

Właściwości

• biological source: rabbit
• Quality Segment: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• species reactivity: human
• technique(s): flow cytometry: 0.25 μg, immunofluorescence: 1:500- 1:2,000, immunoprecipitation (IP): 10 μg/mg
• accession no.: NP_004318.3
• UniProt accession no.: P11274
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: rabbit ... BCR(613)

Opis

Immunogen

The epitope recognized by PLA0233 maps to a region between residue 50 and 100 of human breakpoint cluster region using the numbering given in entry NP_004318.3 (GeneID 613).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

BCR (breakpoint cluster region) was identified as part of a fusion protein that results from a reciprocal translocation with the ABL gene between chromosomes 22 and 9. The BCR-ABL fusion is the cause of chronic myeloid leukemia (CML). The BCR protein contains a C2 domain, a DBL-homology domain, a PH domain, and a Rho-GAP domain and functions as a GTPase-activating protein for RAC1 and CDC42.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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