SAB6012000

Anti ACVR2B Antibody, clone 23GB620, Rabbit Monoclonal

clone 23GB620, recombinant rabbit monoclonal, expressed in HEK293 cells

• Synonim(y): ACTRIIB, ActR-IIB, ACTR-IIB, HTX4
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: 23GB620, recombinant monoclonal
• Application: IF, WB
• Citations: -

Właściwości

• biological source: rabbit (Monoclonal)
• Quality Segment: 100
• recombinant: expressed in HEK 293 cells
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: 23GB620, recombinant monoclonal
• form: buffered aqueous glycerol solution
• mol wt: 58 kDa
• species reactivity: rat, human
• packaging: vial of 1.5 mL
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• sustainability: Sustainability features
• concentration: 0.38 mg/ml
• technique(s): immunofluorescence: 1:100-:1000, western blot: 1:1,000-1:5,000
• isotype: IgG
• Ensembl | human accession no.: ENSG00000114739
• NCBI accession no.: NP_001097.2
• UniProt accession no.: Q13705
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ACVR2B(93)

Opis

General description

Click here to view its DfS scorecard.

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 150-200 of human ACVR2B [NP_001097.2].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• Temperatura zapłonu (°F): 572.0 °F
• Temperatura zapłonu (°C): 300 °C