SML0558

BETP

≥98% (HPLC)

• Synonim(y): 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)-pyrimidine
• Wzór empiryczny (zapis Hilla): C₂₀H₁₇F₃N₂O₂S
• Numer CAS: 1371569-69-5
• Masa cząsteczkowa: 406.42
• NACRES: NA.77
• PubChem Substance ID: 329825551
• UNSPSC Code: 51111800
• MDL number: MFCD23143626
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: CCS(=O)c1nc(cc(n1)C(F)(F)F)-c2cccc(OCc3ccccc3)c2
• InChI: 1S/C20H17F3N2O2S/c1-2-28(26)19-24-17(12-18(25-19)20(21,22)23)15-9-6-10-16(11-15)27-13-14-7-4-3-5-8-14/h3-12H,2,13H2,1H3
• InChI key: NTDFYGSSDDMNHI-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

BETP is a GLP-1 receptor allosteric modulator.

BETP is a positive allosteric modulator of the GLP-1 receptor that potentiates cAMP accumulation and glucose-dependent insulin release in pancreatic islet cells, in the presence of the weak GLP-1 metabolite, GLP-1(9-36). BETP has additive effects on the endogenous GLP-1 receptor ligand GLP-1(7-36).

BetP is a trimeric Na⁺-coupled betaine symporter. BetP belongs to the betaine-choline-carnitine transporter (BCCT) family. It controls transport activity in dependence of the cytoplasmic K⁺-concentration.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable