SML3193

(S)-GSK2920487A

≥98% (HPLC)

• Synonim(y): (S)-(4-fluorobenzo[b]thiophen-2-yl)(3-(5-methyl-1H-imidazol-1-yl)piperidin-1-yl)methanone, (S)-1, TCMDC-143498
• Wzór empiryczny (zapis Hilla): C₁₈H₁₈FN₃OS
• Masa cząsteczkowa: 343.42
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to gray
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(N1C[C@H](CCC1)N2C=CN=C2C)C3=CC4=C(S3)C=CC=C4F
• InChI: 1S/C18H18FN3OS/c1-12-20-7-9-22(12)13-4-3-8-21(11-13)18(23)17-10-14-15(19)5-2-6-16(14)24-17/h2,5-7,9-10,13H,3-4,8,11H2,1H3/t13-/m0/s1
• InChI key: SBZYUUGJHIROPT-ZDUSSCGKSA-N

Opis

Biochem/physiol Actions

(S)-GSK2920487A is a promising anti-leishmanial agent that potently and specifically inhibits oxidosqualene cyclase (OSC) of Leishmania donovani. (S)-GSK2920487A induces the accumulation of the 2,3-oxidosqualene, a substrate of OSC, in promastigotes and cell-free membrane preparations. It is active against axenic and intramacrophage amastigotes. Also, GSK2920487A is active against intracellular T. cruzi.

promising anti-leishmanial agent that potently and specifically inhibits oxidosqualene cyclase (OSC) of Leishmania donovani

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable