SML3396

UCSF678 HYDROCHLORIDE

≥98% (HPLC)

• Synonim(y): 1-(1-(Methylsulfonyl)cyclopropyl)-N-(quinolin-8-ylmethyl)methanamine, 5A6-78, N-[[1-(Methylsulfonyl)cyclopropyl]methyl]-8-quinolinemethanamine
• Wzór empiryczny (zapis Hilla): C₁₅H₁₈N₂O₂S · xHCl
• Masa cząsteczkowa: 290.38 (free base basis)
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C

Opis

Biochem/physiol Actions

Selective, β-arrestin-biased high-affinity 5-HT5A partial agonist. A superior 5-HT5A probe than the non-selective and lower affinity 5-HT5A antagonist SB-699551.

UCSF678 (5A6-78) is a selective, high-affinity (Ki 41.6 nM) β-arrestin-biased 5-HT5A partial agonist (β-arrestin 2 recruitment Emax at 10 μM = 17% of 5-HT Emax) with only off-target affinity toward 1A/2B/7A among >300 GPCRs (>1 μM). UCSF678 is a superior 5-HT5A probe than the non-selective and lower affinity 5-HT5A antagonist SB-699551. The use of UCSF678 shows that 5-HT5AR engagement is nonessential for alleviating pain in a mouse model of peripheral nerve injury-induced mechanical hypersensitivity, which runs contrary to previous studies using less selective ligands.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable