SML4243

Veliparib

≥98% (HPLC), powder, PARP inhibitor

• Synonim(y): 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide, 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide, ABT-888, A 861695, ABT 888
• Wzór empiryczny (zapis Hilla): C₁₃H₁₆N₄O
• Numer CAS: 912444-00-9
• Masa cząsteczkowa: 244.29
• MDL number: MFCD16661059
• NACRES: NA.21
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: -10 to -25°C

Opis

Application

Veliparib may be used in cell proliferation and colony forming assay to study its effect on O 6-methylguanine methyltransferase (MGMT) unmethylated glioblastoma.

Biochem/physiol Actions

Veliparib (ABT-888) is an orally active, potent and selective poly(ADP-ribose) polymerase (PARP) inhibitor (Ki = 5.2 nM PARP1, and 2.9 nM PARP2) that exhibits potent anti-cancer activity. Veliparib blocks DNA damage repair in cancer cells, additionally rendering them more susceptible for other anti-cancer drugs. As a potent PARP1 and PARP2 inhibitor it induces synthetic lethality in cancer cells.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable