5.89591

1,4-Dioxane

anhydrous, 99.8%

• Synonym(s): Diethylene oxide, Dioxane
• Linear Formula: C₄H₈O₂
• CAS Number: 123-91-1
• Molecular Weight: 88.11
• NACRES: NA.22
• UNSPSC Code: 12352005
• Beilstein/REAXYS Number: 102551
• MDL number: MFCD00006571
• Assay: 99.8%
• Grade: anhydrous
• Bp: 100-102 °C (lit.)
• Vapor pressure: 27 mmHg ( 20 °C), 40 mmHg ( 25 °C)

Properties

• grade: anhydrous
• Quality Segment: 200
• vapor density: 3 (vs air)
• vapor pressure: 27 mmHg ( 20 °C), 40 mmHg ( 25 °C)
• assay: 99.8%
• autoignition temp.: 356 °F
• expl. lim.: 22 %
• refractive index: n20/D 1.422 (lit.)
• bp: 100-102 °C (lit.)
• mp: 10-12 °C (lit.)
• density: 1.034 g/mL at 25 °C (lit.)
• SMILES string: C1COCCO1
• InChI: 1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2
• InChI key: RYHBNJHYFVUHQT-UHFFFAOYSA-N

Description

General description

Our anhydrous solvents deliver exceptionally low water content, making them the ideal choice for moisture-sensitive laboratory applications. Packaged in the exclusive Sure/Seal^™ septum bottle system, they are reliably protected against moisture ingress from first use to last drop. The innovative Sure/Seal^™ closure combines an advanced plug-style liner with an airtight elastomer and crimp cap design to ensure consistent product integrity. Three unique liner materials provide optimal chemical compatibility across a broad range of solvents. Sure/Seal^™ packaging is proven to maintain anhydrous conditions even after repeated punctures. With more than 70 products across all major solvent families, available in pack sizes from 100 mL to 2 L, the portfolio meets virtually every laboratory need. By choosing ready-to-use anhydrous solvents in Sure/Seal^™ packaging, researchers eliminate the need for time-consuming and hazardous in-house solvent drying and distillation - saving time, reducing risk, and improving reproducibility.

Application

Anhydrous solvents in Sure/Seal^™ packaging are essential wherever water contamination would compromise experimental results. They are widely used in moisture-sensitive applications such as organic synthesis - including Grignard reactions, organometallic chemistry, and catalysis - as well as in peptide, oligonucleotide, and pharmaceutical synthesis.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• pictograms: GHS02,GHS08,GHS07
• signalword: Danger
• pcodes: P202 - P210 - P233 - P240 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 3 - Flammable liquids
• wgk: WGK 3
• flash_point_f: 51.8 °F - closed cup
• flash_point_c: 11 °C - closed cup
• hcodes: H225,H319,H335,H350
• supp_hazards: EUH019,EUH066