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Tryptophan metabolism: entering the field of aging and age-related pathologies.

Trends in molecular medicine (2013-04-09)
Annemieke T van der Goot, Ellen A A Nollen
ABSTRACT

Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathways, can protect against age-related pathologies and increase lifespan. Recent studies in multiple organisms have implicated tryptophan metabolism as a powerful regulator of age-related diseases and lifespan. Its high conservation throughout evolution has enabled studies that begin to dissect the contribution of individual enzymes and metabolites. Here, we focus on the emerging view of tryptophan metabolism as a pathway that integrates environmental and metabolic signals to regulate animal biology and health.

MATERIALS
Product Number
Brand
Product Description

Tryptophan, European Pharmacopoeia (EP) Reference Standard
Supelco
Tryptophan, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
L-Tryptophan, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-Tryptophan, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0%
Supelco
L-Tryptophan, certified reference material, TraceCERT®
Sigma-Aldrich
L-Tryptophan, BioUltra, ≥99.5% (NT)
Sigma-Aldrich
L-Tryptophan, Vetec, reagent grade, ≥98%