SAE2002
SARS-COV-2-Spike-RBD epitope (480-499)
≥95% (HPLC), lyophilized powder
Synonym(s):
COVID-19 epitope, Immune response epitope, SARS-COV-2 Spike protein peptide
Sign In to View Organizational & Contract Pricing.
Select a Size
100 μG
$474.00
About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Skip To
Product Name
SARS-COV-2-Spike-RBD epitope (480-499), ≥95% (HPLC), lyophilized powder
form
lyophilized powder
solid
species reactivity
viral
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
SARS coronavirus ... S(43740568)
1 of 4
This Item | SAE2000 | SAB4200875 | SAE2001 |
|---|---|---|---|
| species reactivity viral | species reactivity viral | species reactivity viral | species reactivity viral |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| form lyophilized powder, solid | form lyophilized powder, solid | form liquid | form lyophilized powder, solid |
| Gene Information SARS coronavirus ... S(43740568) | Gene Information SARS coronavirus ... S(43740568) | Gene Information - | Gene Information SARS coronavirus ... S(43740568) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| target post-translational modification unmodified | target post-translational modification unmodified | target post-translational modification unmodified | target post-translational modification unmodified |
Application
The peptide may be used in various immunochemical techniques including Immunoblotting and Elisa.
Biochem/physiol Actions
SARS-COV-2-Spike-RBD epitope (480-499) is a synthetic peptide corresponding to the amino acid sequence of Spike RBD region (GeneID: QHD43416.1) in positions 480-499.Peptides derived from the SARS-COV-2-Spike-RBD protein can be recognized by anti-SARS-CoV-2-Spike protein antibodies.
The Spike protein (also known as S protein) is a type I trimeric glycoprotein that is presented on the virion membrane, giving it the appearance of a crown. The protein has two subunits: S1, or bulb, that contains the RBD3-10; and S2, or stalk, responsible for the fusion of the virion with the host cell membrane. The main receptor for SARS-CoV and SARS-CoV-2 on the membrane of the target cells is the Angiotensin 2 Converting Enzyme (ACE2), a metallopeptidase present on the membrane of many cells, including type-I and -II pneumocytes, small intestine enterocytes, kidney proximal tubules cells, the endothelial cells of arteries and veins, and the arterial smooth muscle, among other tissues.15-16
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.Data presented is the available current product information and provided as-is. This product has not been tested or verified in any additional applications, sample types, including any clinical use. Experimental conditions must be empirically derived by the user. Our Antibody Guarantee only covers tested applications stated herein and conditions presented in our product information and is not extended to publications.
General description
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or (2019-nCoV) is a novel coronavirus that emerged in December 2019 and has since infected millions of people worldwide.1 The Spike protein (also known as S protein) is the most studied of the coronaviruses proteins, since it contains the Receptor-Binding-Domain (RBD) for the ligand on the host cell membrane (the ACE2 protein), and also has epitopes recognized by T and B cells.
Physical form
Supplied as a lyophilized powder.Purity: ≥95% (HPLC)
Preparation Note
Store the product at −20 °C. After initial thawing, it is recommended to store the peptide in working aliquots at −20 °C. Recommended thawing solution: Water.
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients.
Bao-Zhong Zhang et al.
Cell research, 30(8), 702-704 (2020-07-03)
Daniel Wrapp et al.
Science (New York, N.Y.), 367(6483), 1260-1263 (2020-02-23)
The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. To facilitate medical
Jian Shang et al.
PLoS pathogens, 16(3), e1008392-e1008392 (2020-03-10)
Coronaviruses recognize a variety of receptors using different domains of their envelope-anchored spike protein. How these diverse receptor recognition patterns affect viral entry is unknown. Mouse hepatitis coronavirus (MHV) is the only known coronavirus that uses the N-terminal domain (NTD)
To Sing Fung et al.
Annual review of microbiology, 73, 529-557 (2019-06-22)
Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus
Chunyan Yi et al.
Cellular & molecular immunology, 17(6), 621-630 (2020-05-18)
Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding domain (RBD), and thus is
Related Content
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service