369079

Guanidine hydrochloride

• Synonym(s): Guanidine Hydrochloride, Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride
• Linear Formula: NH₂C(=NH)NH₂ · HCl
• CAS Number: 50-01-1
• Molecular Weight: 95.53
• NACRES: NA.21
• UNSPSC Code: 12352107
• Beilstein/REAXYS Number: 3591990
• MDL number: MFCD00013026

Properties

• description: Merck USA index - 14 4562
• Quality Segment: 100
• mp: 180-185 °C (lit.)
• density: 1.3 g/cm³ (lit.)
• application(s): advanced drug delivery
• SMILES string: Cl[H].NC(N)=N
• InChI: 1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
• InChI key: PJJJBBJSCAKJQF-UHFFFAOYSA-N

Description

Application

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302 + H332,H315,H319
• Precautionary Statements: P261 - P264 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable