This product is tested for suitability in HPLC. The minimum purity of this material is 97%, and the maximum water content is 2.0 mol. These values are lot-specific and reported in the Certificate of Analysis. This material is not tested for use as an analytical standard. Suitability for this application would have to be determined by the end user. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/p1499#product-documentation
P1499
Pterostilbene
≥97% (HPLC), apoptosis inducer, solid
Synonym(s):
Pterocarpus marsupium, 3,5-Dimethoxy-4′-hydroxystilbene, 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol
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About This Item
Empirical Formula (Hill Notation):
C16H16O3
CAS Number:
Molecular Weight:
256.30
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Pterostilbene, ≥97% (HPLC), solid
Quality Level
Assay
≥97% (HPLC)
form
solid
storage condition
protect from light
solubility
DMSO: >20 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
COc1cc(OC)cc(\C=C\c2ccc(O)cc2)c1
InChI
1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
InChI key
VLEUZFDZJKSGMX-ONEGZZNKSA-N
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Related Categories
1 of 4
This Item | SML1078 | SML1787 | D6571 |
|---|---|---|---|
| form solid | form powder | form powder | form powder |
| assay ≥97% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp |
| storage condition protect from light | storage condition protect from light | storage condition - | storage condition - |
| solubility DMSO: >20 mg/mL, H2O: insoluble | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 3 mg/mL, clear (warmed) | solubility DMSO: ≥20 mg/mL |
General description
Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene), an antioxidant is an analogue of resveratrol. It is present in blueberries, tree wood and some types of grapes.[1]
Application
Pterostilbene has been used:
- to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway[2]
- to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells)[3]
- to study its effects on the cytotoxicity of 2-chloroethyl ethyl sulphide (CEES) in human epidermoid carcinoma cells (A-431) through MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide)viability assay[4]
Biochem/physiol Actions
Antioxidant, antiproliferative, apoptosis inducer, antihyperglycemic, antidiabetic.
Pterostilbene exhibits antineoplastic properties in some of the malignancies, hence it is considered as an active anticancer agent. It has the ability to stimulate apoptosis and block the viability of cell in estrogen-receptor positive and negative breast cancer cell lines.[1]
Disclaimer
Air-sensitive
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 2 - Eye Dam. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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A novel combinatorial epigenetic therapy using resveratrol and pterostilbene for restoring estrogen receptor-alpha (ER alpha) expression in ER alpha-negative breast cancer cells
Kala R and Tollefsbol T O
PLoS ONE, 11(5), e0155057-e0155057 (2016)
Rei Wakimoto et al.
Anticancer research, 37(11), 6153-6159 (2017-10-25)
Although pterostilbene, a natural analog of resveratrol, has potent antitumor activity against several human cancer types, the possible inhibitory mechanisms against subtypes of human breast cancer with different hormone receptor and human epidermal growth factor receptor 2 (HER2) status remain
Keitaro Hagiwara et al.
Scientific reports, 2, 314-314 (2012-03-17)
It is well known that natural products are a rich source of compounds for applications in medicine, pharmacy, and biology. However, the exact molecular mechanisms of natural agents in human health have not been clearly defined. Here, we demonstrate for
Wei Wen et al.
Scientific reports, 7(1), 12754-12754 (2017-10-08)
Endometrial cancer is the most common gynecologic cancer in the United States and its incidence and mortality has been rising over the past decade. Few treatment options are available for patients with advanced and recurring endometrial cancers. Novel therapies, which
Wasamon Nutakul et al.
Journal of agricultural and food chemistry, 59(20), 10964-10970 (2011-09-23)
The effects of resveratrol and pterostilbene (two structurally related stilbene compounds) on three human colon cancer cells were systematically compared. Cell viability tests indicated that IC(50) values of pterostilbene were 2-5-fold lower than those of resveratrol in all three cancer
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Actually we are using as a Analytical Standard for HPLC assay of Pterostilbene in RM and Final Product .Can we use this? if we can use How much purity we have to take for Calculation
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