- Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis.
Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis.
Journal of medicinal chemistry (2006-01-06)
Ravindranadh V Somu, Helena Boshoff, Chunhua Qiao, Eric M Bennett, Clifton E Barry, Courtney C Aldrich
PMID16392788
ABSTRACT
A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC(99) = 0.19 microM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.
MATERIALS