- Effect of ouabain on growth of skin explants in organotypic culture.
Effect of ouabain on growth of skin explants in organotypic culture.
Bulletin of experimental biology and medicine (2013-03-15)
V A Penniyaynen, A V Kipenko, E V Lopatina, B V Krylov
PMID23486569
ABSTRACT
Organotypic culture was used to study the effects of glycoside ouabain and its aglycone ouaba-genin on the growth of skin explants from 10-12-day chicken embryos. The tested agents demonstrated dose-dependent inhibition of skin growth. The effective concentrations imply that ouabain and ouabagenin mediate their inhibitory effect on the skin growth via interaction with α1-isoform of Na(+),K(+)-ATPase that plays mostly the role of ionic pump.