Review of pharmacokinetic, pharmacodynamic and clinical studies with a modern combination of amoxicillin/sulbactam.

Review of pharmacokinetic, pharmacodynamic and clinical studies with a modern combination of amoxicillin/sulbactam.

Chemotherapy (2006-05-25)

J Soutric, C Bantar, N Caruso, R Heguilén, J M Casellas, J M Casellas, A Farinati, A Jasovich, H Arenoso, M Rodriguez

PMID16720984

ABSTRACT

Amoxicillin/sulbactam is a modern antimicrobial combination. This combination proved to be useful for the treatment of several infections caused by different microorganisms, mainly with the beta-lactamase-producing species. In this review we present the most relevant pharmacokinetic, pharmacodynamic and clinical information associated with its use.

MATERIALS

Product Number

Brand

Product Description

A8523

Sigma-Aldrich

Amoxicillin, 95.0-102.0% anhydrous basis

S9701

Sigma-Aldrich

Sulbactam

94876

Supelco

Sulbactam, analytical standard

Y0000528

Sulbactam, European Pharmacopoeia (EP) Reference Standard

Y0000550

Sulbactam for peak identification, European Pharmacopoeia (EP) Reference Standard