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  • Pharmacokinetics of the new progestogens and influence of gestodene and desogestrel on ethinylestradiol metabolism.

Pharmacokinetics of the new progestogens and influence of gestodene and desogestrel on ethinylestradiol metabolism.

Contraception (1997-05-01)
F Z Stanczyk
ABSTRACT

The purpose of the present report is to summarize the most important pharmacokinetic features of the new progestogens. In addition, the question of whether or not gestodene, in comparison to desogestrel, has an influence on the pharmacokinetics of ethinylestradiol (EE2) will be addressed.

MATERIALS
Product Number
Brand
Product Description

Ethinylestradiol for system suitability, European Pharmacopoeia (EP) Reference Standard
Ethinylestradiol, European Pharmacopoeia (EP) Reference Standard
Supelco
Ethinyl Estradiol, Pharmaceutical Secondary Standard; Certified Reference Material
USP
Ethinyl estradiol, United States Pharmacopeia (USP) Reference Standard
Desogestrel, European Pharmacopoeia (EP) Reference Standard
Supelco
17α-Ethynylestradiol, VETRANAL®, analytical standard
Gestodene, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
17α-Ethynylestradiol, ≥98%
Desogestrel for system suitability, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Gestodene, ≥98% (HPLC)