Smart soft-templating synthesis of hollow mesoporous bioactive glass spheres.

Smart soft-templating synthesis of hollow mesoporous bioactive glass spheres.

Chemistry (Weinheim an der Bergstrasse, Germany) (2015-04-23)

Yunqi Li, Bishnu Prasad Bastakoti, Yusuke Yamauchi

ABSTRACT

Hollow bioactive glass spheres with mesoporous shells were prepared by using dual soft templates, a diblock co-polymer poly(styrene-b-acrylic acid) (PS-b-PAA) and a cationic surfactant cetyltrimethylammonium bromide (CTAB). Hollow mesoporous bioactive glass (HMBG) spheres comprise the large hollow interior with vertical mesochannels in shell, which realize large uptake of drugs and their sustained release. The formation of hydroxyapatite layer on the surface of HMBG particles shows the clear evidence for promising application in bone regeneration.

MATERIALS

Product Number

Brand

Product Description

493511

Sigma-Aldrich

Ethyl alcohol, Pure, 190 proof, ACS spectrophotometric grade, 95.0%

487031

Sigma-Aldrich

Sodium bicarbonate-¹²C, 99.9 atom % ¹²C

M8266

Sigma-Aldrich

Magnesium chloride, ≥98%

449172

Sigma-Aldrich

Magnesium chloride, AnhydroBeads^™, −10 mesh, 99.99% trace metals basis

208337

Sigma-Aldrich

Magnesium chloride, powder, <200 μm

H5882

Sigma-Aldrich

Hexadecyltrimethylammonium bromide, ≥98%

H9151

Sigma-Aldrich

Hexadecyltrimethylammonium bromide, BioXtra, ≥99%

52365

Sigma-Aldrich

Hexadecyltrimethylammonium bromide, BioUltra, Molecular Biology, ≥99.0% (AT)

H6269

Sigma-Aldrich

Hexadecyltrimethylammonium bromide, Molecular Biology, ≥99%

C4955

Sigma-Aldrich

Calcium nitrate tetrahydrate, BioXtra, ≥99.0%

C2786

Sigma-Aldrich

Calcium nitrate tetrahydrate, suitable for cell culture, suitable for plant cell culture

538728

Sigma-Aldrich

Triethyl phosphate, ReagentPlus^®, ≥99.8%

P8281

Sigma-Aldrich

Potassium phosphate dibasic, reagent grade, ≥98.0%

450200

Sigma-Aldrich

Potassium phosphate dibasic, 99.95% trace metals basis

60353

Sigma-Aldrich

Potassium phosphate dibasic, anhydrous, suitable for luminescence, Molecular Biology, BioUltra, ≥99.0% (T)

P8584

Sigma-Aldrich

Potassium phosphate dibasic solution, 1.0 M

P2222

Sigma-Aldrich

Potassium phosphate dibasic, meets USP testing specifications

449164

Sigma-Aldrich

Magnesium chloride, AnhydroBeads^™, −10 mesh, 99.9% trace metals basis

M4880

Sigma-Aldrich

Magnesium chloride, suitable for insect cell culture, BioReagent, ≥97.0%

459836

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, anhydrous, ≥99.5%

63036

Sigma-Aldrich

Magnesium chloride solution, BioUltra, Molecular Biology, ~0.025 M in H₂O

S6547

Sigma-Aldrich

Sodium sulfate, BioXtra, ≥99.0%

S5150

Sigma-Aldrich

Sodium chloride solution, 5 M in H₂O, BioReagent, Molecular Biology, suitable for cell culture

2104

Supelco

Hydrochloric acid solution, volumetric, 0.1 M HCl (0.1N), endotoxin free

186562

Sigma-Aldrich

Tetrahydrofuran, anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

P5405

Sigma-Aldrich

Potassium chloride, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99.0%

401757

Sigma-Aldrich

Tetrahydrofuran, anhydrous, ≥99.9%, inhibitor-free

S4019

Sigma-Aldrich

Sodium bicarbonate, Hybri-Max^™, powder, suitable for hybridoma, ≥99.5%

S5761

Sigma-Aldrich

Sodium bicarbonate, powder, BioReagent, Molecular Biology, suitable for cell culture, suitable for insect cell culture

378860

Sigma-Aldrich

Sodium chloride, random crystals, 99.9% trace metals basis