A1388

Adenosine 5′-[γ-thio]triphosphate tetralithium salt

≥75% (HPLC), synthetic (organic), powder

• Synonym(s): ATP-γ-S, Adenosine 5′-(3-thiotriphosphate) tetralithium salt, Ado-5′-PPP[S]
• สูตรเอมพิริกัล (Hill Notation): C₁₀H₁₂Li₄N₅O₁₂P₃S
• CASE番号: 93839-89-5
• น้ำหนักโมเลกุล: 546.98
• NACRES: NA.51
• PubChem Substance ID: 24890536
• eCl@ss: 32160414
• UNSPSC Code: 41106305
• EC Number: 298-862-8
• MDL number: MFCD00077293
• Beilstein/REAXYS Number: 6265083
• Assay: ≥75% (HPLC)
• Biological source: synthetic (organic)
• Form: powder
• Solubility: H₂O: 25 mg/mL
• Storage temp.: −20°C

คุณสมบัติ

• ชื่อสินค้า: Adenosine 5′-[γ-thio]triphosphate tetralithium salt, ≥75% (HPLC), powder
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥75% (HPLC)
• form: powder
• color: white to off-white
• solubility: H₂O: 25 mg/mL
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [Li+].[Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
• InChI key: DWQFDOIBOYDYKH-KWIZKVQNSA-J

คำอธิบาย

Application

Adenosine 5′-[γ-thio]triphosphate tetralithium salt has been used to treat the pollen grains to determine the inhibitory effect of adenosine triphosphate (ATP) or its hydrolysis product. It has also been used to select thiophosphorylate target protein.

Biochem/physiol Actions

Adenosine 5′-[γ-thio]triphosphate (ATP-γ-S) is widely used as a non-hydrolyzed ATP analogue for studies on the effects of ATP binding to ATP sites in a wide range of processes including extracellular functions. ATP- γ-S is a P2 purinergic agonist which increases the activity of Ca²⁺-activated K⁺ channels. ATP- γ-S can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases and modulate the ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome. ATP-γ -S differentially modulates Toll-like receptor 4-mediated cell survival and death.

Other Notes

Non-hydrolyzable ATP analog

ข้อมูลความปลอดภัย

• คลาสการจัดเก็บ: 11 - Combustible Solids
• มีอะไรเกิดขึ้น?: WGK 3
• จุดติดไฟ (°F): Not applicable
• จุดวาบไฟ (°C): Not applicable
• อุปกรณ์ป้องกันส่วนบุคคล (PPE): dust mask type N95 (US), Eyeshields, Gloves