The purpose of the charcoal purification step is to remove fatty acids from the albumin solution, and it has been verified that no traces of charcoal are present in the final product. As for ensuring that components of the buffer used for lyophilization are not present in the final product, it is currently considered salt-free, but there is potential to characterize it by ICP-MS.
A1887
Albumin from human serum
lyophilized powder, essentially fatty acid free
Synonym(s):
HSA
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About This Item
CAS Number:
UNSPSC Code:
12352202
eCl@ss:
42010201
EC Number:
274-272-6
NACRES:
NA.25
MDL number:
Biological source:
human
Assay:
≥96% (agarose gel electrophoresis)
Form:
lyophilized powder
Technique(s):
ELISA: suitable, tissue culture: suitable, western blot: suitable
Impurities:
HIV I and HIVII, HCV and HBsAg, tested negative, ≤0.007% Fatty Acids
Pricing and availability is not currently available.
biological source
human
Quality Segment
assay
≥96% (agarose gel electrophoresis)
form
lyophilized powder
mol wt
monomer calculated mol wt 66478 Da
technique(s)
ELISA: suitable, tissue culture: suitable, western blot: suitable
impurities
HIV I and HIVII, HCV and HBsAg, tested negative, ≤0.007% Fatty Acids
solubility
H2O: soluble 50 mg/mL, clear to slightly hazy
UniProt accession no.
storage temp.
2-8°C
SMILES string
FC(F)(F)C(F)(F)C(F)(F)F
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
Gene Information
human ... ALB(213)
General description
Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa.
Application
Albumin from human serum has been used:
- as a carrier of CPT-11 (irinotecan, Campto) and SN-38 to investigate its binding to human plasma proteins
- to study the adsorption of water and acetonitrile (AN) vapor on a human serum albumin
- to study its effect on wound healing process
Biochem/physiol Actions
Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds. Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood.
Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.
Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport. The albumin levels in the serum indicate the disease progression in advanced liver disease. Low body weight and decreased serum albumin is associated with colorectal cancer.
Preparation Note
Prepared from albumin (A1653)
Other Notes
View more information on human serum albumin.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| description lyophilized powder, essentially fatty acid free | description lyophilized powder, Fatty acid free, Globulin free, ≥99% (agarose gel electrophoresis) | description lyophilized powder, essentially globulin free, ≥99% (agarose gel electrophoresis) | description lyophilized powder, ≥96% (agarose gel electrophoresis) |
| assay ≥96% (agarose gel electrophoresis) | assay ≥99% (agarose gel electrophoresis) | assay ≥99% (agarose gel electrophoresis) | assay ≥96% (agarose gel electrophoresis) |
| biological source human | biological source human | biological source human | biological source human |
| technique(s) western blot: suitable, ELISA: suitable, tissue culture: suitable | technique(s) ELISA: suitable, tissue culture: suitable, western blot: suitable | technique(s) ELISA: suitable, western blot: suitable, tissue culture: suitable | technique(s) tissue culture: suitable, ELISA: suitable, western blot: suitable |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| Gene Information human ... ALB(213) | Gene Information human ... ALB(213) | Gene Information human ... ALB(213) | Gene Information human ... ALB(213) |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves
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What is the purpose of the charcoal purification step, and has it been verified that charcoal is not present in the final product? Additionally, how can it be ensured that components of the buffer used for lyophilization are not present in the final product if they are not tested for on the COA?
1 answer-
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