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A2836

Ansamitocin P-3 from Actinosynnema pretiosum

≥90% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C32H43ClN2O9
CAS Number:
66584-72-3
Molecular Weight:
635.14
NACRES:
NA.32
PubChem Substance ID:
24890696
UNSPSC Code:
12352202
MDL number:
MFCD00274586

Key Documents

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Product Name

Ansamitocin P-3 from Actinosynnema pretiosum, ≥90% (HPLC)

InChI

1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10+/t19-,23+,24-,25+,28-,31+,32+/m1/s1

SMILES string

CO[C@@H]1\C=C\C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)C(C)C)[C@]3(C)O[C@@H]3[C@H](C)[C@@H]4C[C@@]1(O)NC(=O)O4

InChI key

OPQNCARIZFLNLF-KUDLRRJMSA-N

assay

≥90% (HPLC)

form

powder

storage temp.

2-8°C

Quality Level

200

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This Item
N7265N5540SRP6315
Ansamitocin P-3 from Actinosynnema pretiosum ≥90% (HPLC)

Sigma-Aldrich

A2836

Ansamitocin P-3 from Actinosynnema pretiosum

Nitrate Reductase (NAD[P]H) from Aspergillus niger lyophilized powder, ≥300 units/g solid

Sigma-Aldrich

N7265

Nitrate Reductase (NAD[P]H) from Aspergillus niger

Nitrate Reductase (NAD[P]H) From Pichia Pastoris, recombinant freeze-dried protein glass

Sigma-Aldrich

N5540

Nitrate Reductase (NAD[P]H) From Pichia Pastoris, recombinant

Alpha 2 Macroglobulin, Fast Form from human plasma ≥95% (SDS-PAGE)

Sigma-Aldrich

SRP6315

Alpha 2 Macroglobulin, Fast Form from human plasma

assay

≥90% (HPLC)

assay

-

assay

-

assay

≥95% (SDS-PAGE)

form

powder

form

lyophilized powder

form

freeze-dried protein glass

form

lyophilized

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

Biochem/physiol Actions

Fungal metabolite with antineoplastic, antimitotic activity. Binds to tubulin and inhibits vinblastine-induced spiral formation.[1]

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCG1549
SLBS0227V
SLBQ5759V
SLBN9774V
SLBJ2882V

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Florian Taft et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(3), 880-886 (2011-12-16)
Access of four new tumor specific folic acid/ansamitocin conjugates is reported that relies on a synthetic strategy based on the combination of mutasynthesis and semisynthesis. Two bromo-ansamitocin derivatives were prepared by mutasynthesis or by a modified fermentation protocol, respectively, that
The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.
Simone Eichner et al.
Angewandte Chemie (International ed. in English), 51(3), 752-757 (2011-12-03)
Guo-Zhu Wei et al.
Natural product research, 24(12), 1146-1150 (2010-06-29)
A new compound of ansamitocin was isolated from the extracts of fermentation medium of mutant strain HGF052 derived from Actinosynnema pretiosum ssp. aurantium ATCC 31565, and identified as N-demethyl-desepoxy-9-methoxy-maytansinol (1) on the basis of extensive spectroscopic methods. Bioassay results showed
Y Li et al.
Biochemical and biophysical research communications, 187(2), 722-729 (1992-09-16)
The binding of four potent antimitotic agents, rhizoxin (RZX), phomopsin A (PMS-A), ansamitocin P-3 (ASMP-3), and vinblastine (VLB), to tubulins from RZX-sensitive and -resistant strains of Aspergillus nidulans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae was investigated. Mycelial extracts to which RZX
Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.
Kirsten Harmrolfs et al.
Chembiochem : a European journal of chemical biology, 11(18), 2517-2520 (2010-11-16)
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