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C5740

Cytochrome P450 human

2E1 isozyme microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

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About This Item

EC Number:
1.6.2.4 (BRENDA, IUBMB)
MDL number:
MFCD03456520
UNSPSC Code:
12352202
NACRES:
NA.61

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biological source

human

Quality Level

200

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

description

1.0 nmole P450 2E1 per 0.5 ml vial

form

buffered aqueous solution (100 mM potassium phosphate, pH 7.4)

UniProt accession no.

P05181

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CYP2E1(1571)

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This Item
C3735C3860C5614
Cytochrome P450 human 2E1 isozyme microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

Sigma-Aldrich

C5740

Cytochrome P450 human

Cytochrome P450 human 1A1 Isozyme Microsomes, with P450 Reductase, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

Sigma-Aldrich

C3735

Cytochrome P450 human

Cytochrome P450 human 1B1 Isozyme Microsomes, with P450 Reductase, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

Sigma-Aldrich

C3860

Cytochrome P450 human

Cytochrome P450 human 1A2 Isozyme Microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

Sigma-Aldrich

C5614

Cytochrome P450 human

biological source

human

biological source

human

biological source

human

biological source

human

Gene Information

human ... CYP2E1(1571)

Gene Information

human ... CYP1A1(1543)

Gene Information

human ... CYP1B1(1545)

Gene Information

human ... CYP1A2(1544)

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

form

buffered aqueous solution (100 mM potassium phosphate, pH 7.4)

form

solution

form

solution

form

solution

application(s)

cell analysis

application(s)

cell analysis

application(s)

cell analysis

application(s)

cell analysis

UniProt accession no.

P05181

UniProt accession no.

P04798

UniProt accession no.

Q16678

UniProt accession no.

P05177

Application

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Alterations in the renal formation of Cytochrome P450 metabolites from arachidonic acid may participate in the formation of hypertension. Therefore, they have been identified as candidate mediators in the development of this multifactorial disease.

Biochem/physiol Actions

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous. The CYP1A1 isoform catalyzes 7-deethylation of ethoxyresorufin. Cytochrome P450 (CYP) plays an important role in detoxifying xenobiotics, cellular metabolism and homeostasis. One of the main mechanisms of drug-drug interactions is the induction or inhibition of these enzymes. CYP enzymes are transcriptionally activated by a variety of xenobiotics and by endogenous substrates via receptor-dependent pathways. Inhibition of these enzymes is a major factor in metabolism-based drug-drug interactions, and many chemotherapeutic medications can cause drug interactions by either inhibiting or inducing the cytochrome p450 enzyme system.

Analysis Note

Cytochrome c Reductase, b5, P450 content and p-Nitrophenol Hydroxylase activity reported on a lot-specific basis.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCK1380
SLBP6476V
SLBD6031V
031M1398
100M1644

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Mong-Heng Wang et al.
Hypertension (Dallas, Tex. : 1979), 42(4), 594-599 (2003-08-27)
The incidence of essential hypertension increases with obesity; however, the mechanisms that link obesity with hypertension are unclear. Renal cytochrome P450 (CYP)-derived eicosanoids--hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DHETs)--have been shown to play an important role in
Xiangrong Zhang et al.
PloS one, 9(4), e94962-e94962 (2014-04-17)
The present study characterized in vitro metabolites of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(R)-25-OCH3-PPD) in mouse, rat, dog, monkey and human liver microsomes. 20(R)-25-OCH3-PPD was incubated with liver microsomes in the presence of NADPH. The reaction mixtures and the metabolites were identified
Mirza Bojić et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1438-1446 (2014-07-06)
Cilengitide is a stable cyclic pentapeptide containing an Arg-Gly-Asp motif responsible for selective binding to αVβ3 and αVβ5 integrins. The candidate drug showed unexpected inhibition of cytochrome P450 (P450) 3A4 at high concentrations, that is, a 15-mM concentration caused attenuation
Dongju Lin et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1727-1736 (2014-07-16)
Diosbulbin B (DIOB), a furan-containing diterpenoid lactone, is the most abundant component of Dioscorea bulbifera L. (DB), a traditional Chinese medicine herb. Administration of purified DIOB or DB extracts has been reported to cause liver injury in animals. The mechanisms

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