This product is an MQ Level 200 and suitable for research use only. It would not be suitable for the production of a pharmaceutical product. Currently, there is no L-(?)-Malic acid offered that is suitable for this application.
M7397
L-(−)-Malic acid
suitable for cell culture, BioReagent, suitable for insect cell culture
Synonym(s):
(S)-(−)-2-Hydroxysuccinic acid, L-Hydroxybutanedioic acid
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About This Item
Linear Formula:
HO2CCH2CH(OH)CO2H
CAS Number:
Molecular Weight:
134.09
Beilstein:
1723541
EC Number:
MDL number:
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.75
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biological source
microbial
product line
BioReagent
Assay
≥95% (titration)
form
powder
technique(s)
cell culture | insect: suitable
cell culture | mammalian: suitable
mp
101-103 °C (lit.)
solubility
water: 100 mg/mL, clear to slightly hazy, colorless
SMILES string
O[C@@H](CC(O)=O)C(O)=O
InChI
1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChI key
BJEPYKJPYRNKOW-REOHCLBHSA-N
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This Item | 09172 | M6413 | 8.00384 |
|---|---|---|---|
| assay ≥95% (titration) | assay - | assay ≥95% | assay ≥99% (acidimetric) |
| Quality Level 200 | Quality Level 300 | Quality Level 200 | Quality Level 200 |
| form powder | form - | form powder | form powder |
| solubility water: 100 mg/mL, clear to slightly hazy, colorless | solubility - | solubility H2O: 0.5 M at 20 °C, clear, colorless | solubility 160 g/L |
| mp 101-103 °C (lit.) | mp 101-103 °C (lit.) | mp 101-103 °C (lit.) | mp 98-103 °C |
| biological source microbial | biological source - | biological source - | biological source - |
General description
Application
Biochem/physiol Actions
Malic acid is a part of cellular metabolism. Its application is recognized in pharmaceutics. It is useful in the treatment of hepatic malfunctioning, effective against hyper-ammonemia. It is used as a part of amino acid infusion.[6] Malic acid also serves as a nanomedicine in the treatment of brain neurological disorders.[7] A TCA (Krebs cycle) intermediate and partner in the malic acid aspartate shuttle.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system
Sauerbeck A, et al.
Journal of Neuroscience Methods, 198(1), 36-43 (2011)
Continuous production of L-malic acid by immobilized Brevibacterium ammoniagenes cells
Yamamoto K, et al.
Europ. J. Appl. Microbiol. Biotechnol., 3(3), 169-183 (1976)
Invertebrate Tissue Culture, 11-11 (2012)
Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus
Doherty E, et al.
Antioxidants & Redox Signaling, 21(1), 56-65 (2014)
Biotechnology, 238-238 (1990)
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What is the quality level of this product? (I would like to use it as an ingredient in a medium to cultivate cells to be used as starting material for a pharmaceutical product, do you have other suggestions?)
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