W2020
WR-1065
≥98% (HPLC), reactive oxygen species scavenger, powder
同義詞:
2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride, WR-1065 dihydrochloride
登入 檢視組織與合約價格。
選擇尺寸
變更視圖
| 包裝尺寸 | 庫存單位 | 供貨能力 | 價格 |
|---|
關於此項目
經驗公式（希爾表示法）:
C5H14N2S · 2HCl
CAS 編號:
分子量：:
207.16
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
暫時無法取得訂價和供貨情況
產品名稱
WR-1065, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
H2O: ≥20 mg/mL
storage temp.
−20°C
SMILES string
Cl.Cl.NCCCNCCS
InChI
1S/C5H14N2S.2ClH/c6-2-1-3-7-4-5-8;;/h7-8H,1-6H2;2*1H
InChI key
XDRLRDHLCIFZIW-UHFFFAOYSA-N
Biochem/physiol Actions
WR-1065 is a cytoprotective cell-permeable ROS scavenge and an active metabolite of Amifostine.
WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy.
WR-1065 is the active metabolite of the prodrug amifostine, generated by alkaline phosphatase. It is found to accumulate in many epithelial tissues. WR-1065 protects cellular membranes and DNA from free radical induced damage.
1 of 1
本產品 | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. room temp | storage temp. −20°C | storage temp. 2-8°C |
| solubility H2O: ≥20 mg/mL | solubility H2O: >15 mg/mL | solubility H2O: 20 mg/mL, clear | solubility H2O: 20 mg/mL, clear |
| storage condition desiccated | storage condition desiccated | storage condition desiccated | storage condition desiccated |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
存儲類別/等級
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
David R Cassatt et al.
International journal of radiation oncology, biology, physics, 61(3), 901-907 (2005-02-15)
The cytoprotective drug amifostine (Ethyol) protects rats from oral mucositis resulting from a single dose of gamma-irradiation. We expanded earlier studies to determine whether multiple doses of amifostine protect against fractionated or hyperfractionated radiation and whether the active metabolite of
J S Murley et al.
Free radical biology & medicine, 51(10), 1918-1925 (2011-09-29)
Manganese superoxide dismutase (SOD2)-mediated adaptive processes that protect against radiation-induced micronucleus formation can be induced in cells after a 2-Gy exposure by previously exposing them to either low-dose ionizing radiation (10cGy) or WR1065 (40μM), the active thiol form of amifostine.
Zaki S Badawy et al.
Fertility and sterility, 91(1), 173-178 (2008-01-22)
To determine the effect of 4-hydroperoxycyclophosphamide (4OOH-CP) on the respiration of human sperm, and investigate the protective properties of mesna and WR-1065. SUNY Upstate Medical University, Syracuse, NY. Men (n = 12) visited the Andrology Department for fertility evaluation. None.