MilliporeSigma

NOTCH2

notch 2

Synonyms:
AGS2, HJCYS, hN2
Species:
UniProtKB ID:
Gene ID:
  • Human(4853) Summary: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
  • Mouse(18129) notch 2
  • Rat(29492) notch 2
  • cow(513730) notch 2
  • sheep(101112098) notch 2
  • domestic cat(101091800) notch 2
  • Horse(100067078) notch 2
  • dog(483148) notch 2
  • chicken(374031) notch 2
  • Zebrafish(58065) notch homolog 2
  • domestic guinea pig(100715372) notch 2
  • naked mole-rat(101712759) notch 2

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Rat Notch-2 ELISA, for serum, plasma and cell culture supernatants,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Notch 2 Antibody, NT, serum, from rabbit,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-NOTCH2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-NOTCH2 (Cleaved-Val1697) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-NOTCH2 (Cleaved-Ala1734) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-NOTCH2 (Cleaved-Asp1733) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
DAPT, ≥98% (HPLC), solid,
Species
mouse, human, rat
L-685,458, >96% (HPLC), solid,
Species
mouse, human, rat

Proteins

Product Number
Description
Species
PrEST Antigen NOTCH2, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
Species
human
Notch-2/Fc Chimera from rat, recombinant, expressed in NSO cells, ≥90% (SDS-PAGE), lyophilized powder,
Species
rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human NOTCH2,
Species
human