MilliporeSigma

BRCA1

breast cancer 1, early onset

Synonyms:
BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
Species:
UniProtKB ID:
Gene ID:
  • Human(672) Summary: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
  • Mouse(12189) breast cancer 1
  • Rat(497672) breast cancer 1, early onset
  • domestic cat(101081937) breast cancer 1, early onset
  • domestic guinea pig(100722339) breast cancer 1, early onset
  • naked mole-rat(101705460) breast cancer 1, early onset
  • sheep(101108584) breast cancer 1, early onset
  • Domestic Rabbit(100347269) breast cancer 1, early onset
  • cow(353120) breast cancer 1, early onset
  • domestic cat(493761) breast cancer 1, early onset
  • Horse(100051990) breast cancer 1, early onset
  • dog(403437) breast cancer 1, early onset
  • chicken(373983) breast cancer 1, early onset
  • Thale Cress(827854) protein BREAST CANCER SUSCEPTIBILITY 1-like protein

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Rabbit anti-Phospho BRCA1 (S1524) Antibody, Affinity Purified, ,
Species Reactivity
human
Application
proximity ligation assay
western blot
Rabbit anti-BRCA1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-phospho-BRCA1 (pSer1423) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
Anti-BRCA1 (Ab-1524) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-BRCA1 (Ab-1423) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot

Kits

Product Number
Description
Species
CpG WIZ BRCA1 -Methylation specific PCR assay, Methylation-specific PCR (MSP), performed using the CpGenome DNA Modification Kit & the CpG WIZ BRCA1 Amplification Kit, permits sensitive detection of altered DNA.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human BRCA1,
Species
human
MISSION® esiRNA, targeting mouse Brca1,
Species
mouse