MilliporeSigma

CD74

CD74 molecule, major histocompatibility complex, class II invariant chain

Synonyms:
DHLAG, HLADG, II, Ia-GAMMA
Species:
UniProtKB ID:
Gene ID:
  • Human(972) Summary: The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  • Mouse(16149) CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
  • Rat(25599) Cd74 molecule, major histocompatibility complex, class II invariant chain
  • cow(613384) CD74 molecule, major histocompatibility complex, class II invariant chain
  • domestic cat(101085953) CD74 molecule, major histocompatibility complex, class II invariant chain
  • domestic guinea pig(100735496) CD74 molecule, major histocompatibility complex, class II invariant chain
  • dog(479329) CD74 molecule, major histocompatibility complex, class II invariant chain
  • sheep(101102561) CD74 molecule, major histocompatibility complex, class II invariant chain
  • chicken(414741) CD74 molecule, major histocompatibility complex, class II invariant chain
  • naked mole-rat(101723625) CD74 molecule, major histocompatibility complex, class II invariant chain

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ELISA

Product Number
Description
Species
Human CD74 ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-MHC class II (I-A/I-E), redFluor® 710, clone M5/114 .15.2 Antibody, clone M5/114.15.2, from rat, redFluor® 710,
Species Reactivity
mouse
Application
flow cytometry
Anti-MHC class II (I-A/I-E), violetFluor® 450, clone M5/114 .15.2 Antibody, clone M5/114.15.2, from rat, violetFluor® 450,
Species Reactivity
mouse
Application
flow cytometry
Monoclonal Anti-CD74-Allophycocyanin antibody produced in mouse, clone 3D7,
Species Reactivity
human
Application
flow cytometry
western blot
Monoclonal Anti-CD74-Biotin antibody produced in mouse, clone 6D9,
Species Reactivity
human
Application
immunofluorescence
western blot
Monoclonal Anti-CD74-Atto 488 antibody produced in mouse, clone 6D9,
Species Reactivity
human
Application
immunofluorescence
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CD74,
Species
human
MISSION® esiRNA, targeting mouse Cd74,
Species
mouse