MilliporeSigma

ERBB2

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

Synonyms:
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Species:
UniProtKB ID:
Gene ID:
  • Human(2064) Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13866) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Rat(24337) v-erb-b2 avian erythroblastic leukemia viral oncogene 2
  • domestic guinea pig(100727657) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • naked mole-rat(101705227) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Zebrafish(386966) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • chicken(426130) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • dog(403883) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • domestic cat(751824) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Horse(100054739) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • cow(505709) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
  • sheep(780519) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Domestic Rabbit(100009554) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

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ELISA

Product Number
Description
Species
Phosphotyrosine ERBB2 / Receptor Tyrosine-protein Kinase erbB-2 ELISA Kit, ,
Species
human
Human ErbB2 / HER2 ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-HER2 (pTyr1221/Tyr1222) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-ERBB2 (Ab-1221/1222) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-phospho-ERBB2 (pTyr1248) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-c-erbB-2 antibody produced in mouse, ~2 mg/mL, clone HER2-96, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)

microarray
Anti-HER2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

Cell Lines

Product Number
Description
Species
MCF10A CELLS HER2 (-/-) EXON 2, ,
Species
human
MCF10A CELLS HER2 (-/-), ,
Species
human
SKOV3 Cells GFP-HER2, ,
Species
human
SKOV3 Cells GFP-HER2 RFP-EGFR, ,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Mubritinib, ≥98% (HPLC),
Species
human
CP724714, ≥98% (HPLC),
Species
human
Tyrphostin AG 879, 99% (HPLC),
Species
human
Lapatinib, ≥98% (HPLC),
Species
human
Lapatinib, ,
Species
human

Proteins

Product Number
Description
Species
HER2 (676-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ERBB2,
Species
human
MISSION® esiRNA, targeting mouse Erbb2,
Species
mouse