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GRN

granulin

Synonyms:
CLN11, GEP, GP88, PCDGF, PEPI, PGRN
Species:
UniProtKB ID:
Gene ID:
  • Human(2896) Summary: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
  • Mouse(14824) granulin
  • Rat(29143) granulin
  • fruit fly(40962) grain
  • dog(480501) granulin
  • Horse(100051035) granulin
  • domestic cat(101100680) granulin
  • cow(767942) granulin
  • sheep(101115470) granulin
  • Domestic Rabbit(100349528) granulin
  • domestic guinea pig(100135533) granulin
  • naked mole-rat(101715753) granulin

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ELISA

Product Number
Description
Species
Human PGRN ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Species
human
Mouse Grn / Granulins ELISA Kit, ,
Species
mouse

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-GRN antibody produced in mouse, clone 1F5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
Anti-GRN antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Monoclonal Anti-GRN antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL5692, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-GRN antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL5695, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-Granulin (C-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot

Proteins

Product Number
Description
Species
Progranulin human, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE),
Species
human
Granulin C human, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE),
Species
human
Progranulin mouse, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE),
Species
mouse
Progranulin rat, recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE),
Species
rat
Progranulin mouse, recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE),
Species
mouse

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GRN,
Species
human
MISSION® esiRNA, targeting mouse Grn,
Species
mouse