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LRP2

low density lipoprotein receptor-related protein 2

Synonyms:
DBS, GP330
Species:
UniProtKB ID:
Gene ID:
  • Human(4036) Summary: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
  • Mouse(14725) low density lipoprotein receptor-related protein 2
  • Rat(29216) low density lipoprotein receptor-related protein 2
  • domestic guinea pig(100713603) low density lipoprotein receptor-related protein 2
  • naked mole-rat(101717800) low density lipoprotein receptor-related protein 2
  • domestic cat(101087337) low density lipoprotein receptor-related protein 2
  • Horse(100062836) low density lipoprotein receptor-related protein 2
  • cow(100337021) low density lipoprotein receptor-related protein 2
  • dog(478781) low density lipoprotein receptor-related protein 2
  • Domestic Rabbit(100346275) low density lipoprotein receptor-related protein 2
  • sheep(101108200) low density lipoprotein receptor-related protein 2
  • chicken(424168) low density lipoprotein receptor-related protein 2

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-LRP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-LRP2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-LRP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
ANTI-LRP2 (MEGALIN) (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
Anti-LRP-2/Megalin Antibody, clone 10D5.1, clone 10D5.1, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human LRP2,
Species
human
MISSION® esiRNA, targeting mouse Lrp2,
Species
mouse