MilliporeSigma

MAP2K1

mitogen-activated protein kinase kinase 1

Synonyms:
CFC3, MAPKK1, MEK1, MKK1, PRKMK1
Species:
UniProtKB ID:
Gene ID:
  • Human(5604) Summary: The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
  • Mouse(26395) mitogen-activated protein kinase kinase 1
  • Rat(170851) mitogen activated protein kinase kinase 1
  • domestic guinea pig(100712888) mitogen-activated protein kinase kinase 1
  • dog(478347) mitogen-activated protein kinase kinase 1
  • Horse(100065996) mitogen-activated protein kinase kinase 1
  • domestic cat(101081387) mitogen-activated protein kinase kinase 1
  • chicken(415549) mitogen-activated protein kinase kinase 1
  • naked mole-rat(101715628) mitogen-activated protein kinase kinase 1
  • cow(533199) mitogen-activated protein kinase kinase 1
  • Domestic Rabbit(100009316) mitogen-activated protein kinase kinase 1
  • sheep(101123635) mitogen-activated protein kinase kinase 1
  • Zebrafish(406728) mitogen-activated protein kinase kinase 1

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ELISA

Product Number
Description
Species
Phosphotyrosine MAP2K1 ELISA Kit, ,
Species
human
Phospho-Mek (pSer217 / 221) ELISA Kit, for detection of phospho-mek (pSer217 / 221) in human, mouse or rat cell and tissue lysates,
Species
human
Phospho-Mek (pSer217 / 221) and pan-Mek ELISA Kit, for detection of phospho-mek (pSer217 / 221) and pan-mek in human, mouse or rat cell and tissue lysates,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-MAP2K1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-phospho-MAP2K1 (pThr386) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-MEK1 Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
Anti-MAP2K1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-Phospho-MAP2K1-pS221 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
U0126, U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.,
Species
human
U0126 ethanolate, ≥98% (HPLC), powder,
Species
human
PD184352, ≥98% (HPLC),
Species
human
PD 98,059, solid,
Species
human

Proteins

Product Number
Description
Species
MEK1 Protein, active, 10 µg, Active, N-terminal GST & C-terminal His6-tagged, recombinant full-length human MEK1, for use in Kinase Assays.,
Species
human
MEK1 Protein, inactive, 50 g, Unactive, N-terminal GST & C-terminal His6-tagged, recombinant full-length human MEK1, for use in Kinase Assays.,
Species
human
MEK1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
mouse

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Map2k1,
Species
mouse
MISSION® esiRNA, targeting human MAP2K1,
Species
human