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MAP2K4

mitogen-activated protein kinase kinase 4

Synonyms:
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
Species:
UniProtKB ID:
Gene ID:
  • Human(6416) Summary: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul 2008]
  • Mouse(26398) mitogen-activated protein kinase kinase 4
  • Rat(287398) mitogen activated protein kinase kinase 4
  • domestic cat(101086432) mitogen-activated protein kinase kinase 4
  • Domestic Rabbit(100344852) mitogen-activated protein kinase kinase 4
  • chicken(417312) mitogen-activated protein kinase kinase 4
  • dog(489508) mitogen-activated protein kinase kinase 4
  • sheep(101115045) mitogen-activated protein kinase kinase 4
  • Horse(100073094) mitogen-activated protein kinase kinase 4
  • domestic guinea pig(100733674) mitogen-activated protein kinase kinase 4
  • naked mole-rat(101705822) mitogen-activated protein kinase kinase 4
  • cow(526469) mitogen-activated protein kinase kinase 4

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-SEK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-SEK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry
Anti-JNKK, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-SEK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
Anti-Phospho-MAP2K4-S257/T261 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
PD 98,059, solid,
Species
human

Proteins

Product Number
Description
Species
MKK4/SKK1 Protein, inactive, 50 g, Unactive, recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an N-terminal GST-tag, for use in Kinase Assays.,
Species
mouse
MKK4/SKK1 Protein, active, 10 µg, Active, N-terminal GST tagged, murine MKK4 residues 34-end, for use in Kinase Assays.,
Species
mouse

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Map2k4,
Species
mouse
MISSION® esiRNA, targeting human MAP2K4,
Species
human