MilliporeSigma

MAP3K5

mitogen-activated protein kinase kinase kinase 5

Synonyms:
ASK1, MAPKKK5, MEKK5
Species:
UniProtKB ID:
Gene ID:
  • Human(4217) Summary: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
  • Mouse(26408) mitogen-activated protein kinase kinase kinase 5
  • Rat(365057) mitogen-activated protein kinase kinase kinase 5
  • chicken(421688) mitogen-activated protein kinase kinase kinase 5
  • domestic cat(101082912) mitogen-activated protein kinase kinase kinase 5
  • dog(476215) mitogen-activated protein kinase kinase kinase 5
  • Zebrafish(555703) mitogen-activated protein kinase kinase kinase 5
  • sheep(101121018) mitogen-activated protein kinase kinase kinase 5
  • cow(537380) mitogen-activated protein kinase kinase kinase 5
  • Horse(100073186) mitogen-activated protein kinase kinase kinase 5
  • naked mole-rat(101712051) mitogen-activated protein kinase kinase kinase 5
  • domestic guinea pig(100722979) mitogen-activated protein kinase kinase kinase 5

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Phospho-MAP3K5-T918 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Phospho-MAP3K5-S1033 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Phospho-MAP3K5-S83 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Anti-phospho-MAP3K5 (pSer83) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-MAP3K5 (Ab-966) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunofluorescence
immunohistochemistry

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Map3k5,
Species
mouse
MISSION® esiRNA, targeting human MAP3K5,
Species
human