MilliporeSigma

MAPK8

mitogen-activated protein kinase 8

Synonyms:
JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
Species:
UniProtKB ID:
Gene ID:
  • Human(5599) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]
  • Mouse(26419) mitogen-activated protein kinase 8
  • Rat(116554) mitogen-activated protein kinase 8
  • chicken(423778) mitogen-activated protein kinase 8
  • cow(539941) mitogen-activated protein kinase 8
  • Goat(100861087) mitogen-activated protein kinase 8
  • domestic cat(101091310) mitogen-activated protein kinase 8
  • Horse(100051798) mitogen-activated protein kinase 8
  • dog(477746) mitogen-activated protein kinase 8
  • Domestic Rabbit(100346929) mitogen-activated protein kinase 8
  • sheep(101116201) mitogen-activated protein kinase 8
  • domestic guinea pig(100722333) mitogen-activated protein kinase 8
  • naked mole-rat(101715259) mitogen-activated protein kinase 8

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ELISA

Product Number
Description
Species
Cell-Based ELISA for detecting phospho-JNK (pThr183 / pTyr185) in cultured cell lines, 96 assays,
Species
human
Phosphotyrosine MAPK8 / Mitogen-activated Protein Kinase 8 ELISA Kit, ,
Species
human
Cell-Based ELISA Sampler Kit for detecting phospho-ERK1/2 (pThr202/pTyr204), phospho-JNK (pThr183/pTyr185), and phospho-p38 MAPK (pThr180/pTyr182) in cultured cell lines, 192 assays,
Species
rat, human, mouse

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-JNK1/2 (pThr183/pTyr185) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, rat
Application
immunocytochemistry
immunofluorescence

immunohistochemistry

western blot
Anti-MAPK8 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, rat
Application
immunofluorescence
western blot
Anti-phospho JNK (Thr183, Tyr185) Antibody, clone 3F7, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunohistochemistry

inhibition assay

western blot
Anti-JNK1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-Phospho-JNK1/2-T183/Y185 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Adenine, BioReagent, suitable for cell culture,
Species
human, rat, mouse
Adenine, BioReagent, suitable for plant cell culture, ≥99%,
Species
human, rat, mouse
Adenine, ≥99%,
Species
human, rat, mouse
α-Sexithiophene, ,
Species
human, rat

Proteins

Product Number
Description
Species
JNK1, active, GST tagged from mouse, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE), buffered aqueous glycerol solution,
Species
mouse
JNK1α1/SAPK1c Protein, active, 10 µg, Active, recombinant full-length human JNK1α1/SAPK1c with an N-terminal His-tag, for use in Kinase Assays.,
Species
human
JNK1α1/SAPK1c Protein, inactive, 50 g, Unactive, N-terminal His6-tagged recombinant, human, full-length JNK1α1/SAPK1c, for use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MAPK8,
Species
human
MISSION® esiRNA, targeting mouse Mapk8,
Species
mouse