MilliporeSigma

NOS1

nitric oxide synthase 1 (neuronal)

Synonyms:
IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS
Species:
UniProtKB ID:
Gene ID:
  • Human(4842) Summary: The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
  • Mouse(18125) nitric oxide synthase 1, neuronal
  • Rat(24598) nitric oxide synthase 1, neuronal
  • Domestic Rabbit(100009243) nitric oxide synthase 1 (neuronal)
  • naked mole-rat(101711993) nitric oxide synthase 1 (neuronal)
  • cow(536132) nitric oxide synthase 1 (neuronal)
  • domestic cat(101100342) nitric oxide synthase 1 (neuronal)
  • Zebrafish(60658) nitric oxide synthase 1 (neuronal)
  • Horse(100051079) nitric oxide synthase 1 (neuronal)
  • dog(477498) nitric oxide synthase 1 (neuronal)
  • chicken(427721) nitric oxide synthase 1 (neuronal)
  • domestic guinea pig(100729682) nitric oxide synthase 1 (neuronal)

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Small Molecule - Antagonist

Product Number
Description
Species
(+)-Thalidomide, ≥98% (HPLC), powder,
Species
human, mouse, rat
(−)-Thalidomide, >98%, solid,
Species
human, mouse, rat
Ammonium pyrrolidinedithiocarbamate, ~99%,
Species
human
Melatonin, powder, ≥98% (TLC),
Species
human
Nω-Nitro-L-arginine, ≥98% (TLC),
Species
rat, mouse, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-n-NOS (pSer852) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-phospho-n-NOS (pSer852) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-NOS1 (Ab-852) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
Anti-Nitrotyrosine Antibody, Upstate®, from rabbit,
Species Reactivity
all
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Nitrotyrosine Mouse mAb (CC22.8C7.3), liquid, clone CC22.8C7.3, Calbiochem®,
Species Reactivity
all
Application

Small Molecule - Inhibitor

Product Number
Description
Species
5-Methyl-2-nitroaniline, 95%,
Species
rat
4-Nitrocatechol, ≥96.0%,
Species
rat
Spermidine trihydrochloride, ≥98% (TLC),
Species
human
1400W dihydrochloride, >98%, solid,
Species
human
7,7,8,8-Tetracyanoquinodimethane, 98%,
Species
rat, human

Kits

Product Number
Description
Species
Nitric Oxide Synthase Detection System, Fluorimetric, sufficient for 200 reactions,
Species
human

Small Molecule - Precursor

Product Number
Description
Species
L-Arginine, ,
Species
rat, human
L-Arginine, BioUltra, ≥99.5% (NT),
Species
rat, human
L-Arginine, reagent grade, ≥98%,
Species
rat, human
L-Arginine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%,
Species
rat, human
L-Arginine, 99%, FCC, FG,
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Nos1,
Species
mouse