MilliporeSigma

PDE4B

phosphodiesterase 4B, cAMP-specific

Synonyms:
DPDE4, PDE4B5, PDEIVB
Species:
UniProtKB ID:
Gene ID:
  • Human(5142) Summary: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Mouse(18578) phosphodiesterase 4B, cAMP specific
  • Rat(24626) phosphodiesterase 4B, cAMP specific
  • naked mole-rat(101703441) phosphodiesterase 4B, cAMP-specific
  • domestic guinea pig(100720296) phosphodiesterase 4B, cAMP-specific
  • chicken(424700) phosphodiesterase 4B, cAMP-specific
  • domestic cat(101081316) phosphodiesterase 4B, cAMP-specific
  • dog(479540) phosphodiesterase 4B, cAMP-specific
  • cow(100124505) phosphodiesterase 4B, cAMP-specific
  • Horse(100053961) phosphodiesterase 4B, cAMP-specific
  • Domestic Rabbit(100355058) phosphodiesterase 4B, cAMP-specific
  • sheep(101111757) phosphodiesterase 4B, cAMP-specific

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Small Molecule - Antagonist

Product Number
Description
Species
Pentoxifylline, solid,
Species
human, rat
Caffeine, anhydrous, 99%, FCC, FG,
Species
mouse, human, rat
Caffeine, anhydrous, tested according to Ph. Eur.,
Species
mouse, human, rat
Caffeine, Sigma Reference Standard, vial of 250 mg,
Species
mouse, human, rat
Caffeine, BioXtra,
Species
mouse, human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PDE4B2 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, rat
Application
western blot
Anti-PDE4B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-PDE4B Antibody, clone 1E9 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse
Application
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-PDE4B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Papaverine hydrochloride, powder,
Species
human
Roflumilast, ≥98% (HPLC),
Species
human
Amlexanox, ≥98% (HPLC),
Species
human
Zaprinast, solid,
Species
human
Ibudilast, ≥99% (HPLC), solid,
Species
human

Proteins

Product Number
Description
Species
PDE4B1 Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
rat
PrEST Antigen PDE4B, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
Species
human
PDE4B2 Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Pde4b,
Species
mouse
MISSION® esiRNA, targeting human PDE4B,
Species
human