Skip to Content
MilliporeSigma

SMARCA4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Synonyms:
BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b
Species:
UniProtKB ID:
Gene ID:
  • Human(6597) Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
  • Mouse(20586) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • Rat(171379) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • dog(476710) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • sheep(101116565) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • domestic cat(101097046) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • Zebrafish(353295) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • chicken(395932) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • cow(414274) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • naked mole-rat(101700987) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • domestic guinea pig(100719729) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-SNF2β/BRG1 Antibody, serum, Upstate®,
Species Reactivity
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
Anti-SMARCA4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-SMARCA4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Monoclonal Anti-Smarca4 Antibody Produced In Mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL13779, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
western blot
Anti-BRG1/SMARCA4 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot

Proteins

Product Number
Description
Species
BRG1 (1480-1603) His tag human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Species
human
BRG1, wild type human, recombinant, expressed in insect cells, ≥80% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human SMARCA4,
Species
human