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TOP2A

topoisomerase (DNA) II alpha 170kDa

Synonyms:
TOP2, TP2A
Species:
UniProtKB ID:
Gene ID:
  • Human(7153) Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
  • Mouse(21973) topoisomerase (DNA) II alpha
  • Rat(360243) topoisomerase (DNA) II alpha
  • dog(480525) topoisomerase (DNA) II alpha 170kDa
  • Domestic Rabbit(100357676) topoisomerase (DNA) II alpha 170kDa
  • Zebrafish(323733) topoisomerase (DNA) II alpha
  • chicken(395570) topoisomerase (DNA) II alpha 170kDa
  • sheep(101108762) topoisomerase (DNA) II alpha 170kDa
  • domestic guinea pig(100730168) topoisomerase (DNA) II alpha 170kDa
  • cow(787696) topoisomerase (DNA) II alpha 170kDa
  • domestic cat(101083813) topoisomerase (DNA) II alpha 170kDa

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-TOP2A (pSer1106) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-phospho-TOP2A (pThr1343) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-Topoisomerase II Antibody, clone KiS1, clone KiS1, Chemicon®, from mouse,
Species Reactivity
human
Application
flow cytometry
immunocytochemistry

immunohistochemistry

western blot
Monoclonal Anti-TOP2A antibody produced in mouse, clone 1E2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-DNA topoisomerase II alpha (TOP2A) Antibody, clone 8V9C8, Rabbit Monoclonal, ,
Species Reactivity
mouse
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Doxorubicin hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Mitoxantrone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Mitoxantrone hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Doxorubicin hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Doxorubicin Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human

Proteins

Product Number
Description
Species
Topoisomerase II α human, (Single band on SDS-PAGE), liquid,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human TOP2A,
Species
human
MISSION® esiRNA, targeting mouse Top2a,
Species
mouse